Our lead


Monoclonal antibody

Intraveinous route of administration - monthly administration

Companion biomarkers - inclusion tool

Our project



ENCEFA has identified an unprecedented mechanism of action by modulating CD38 (specific epitope), an age-related target highly expressed in the brain and the immune system, whose expression is highly dysregulated in neuro-degenerative and auto-immune diseases and others pathologies with inflammatory compound.


While drugs currently under development directly involve a unique pathway at a time, our antibodies trigger pleiotropic strong beneficial effects by regulating through its target autophagy, metabolism and inflammation, three shared key deleterious mechanisms at play in several age-related, auto-immune and inflammatory diseases.


Among these beneficial effects, strong neuro-protection and immuno-modulation have been shown in several preclinical in vivo models, including preliminary results in post-conditioning (when disease is installed). 

Thus, ENCEFA's antibody represents a promising advance against several pathologies that a still anmet medical needs, facing the complexity of these pathologies in a clinical stage.


ENCEFA's first indication will be the Amyotrophic Lateral Sclerosis. First human clinical trials are planned to be launched in Q3 2021, with the ambition to tackle a wide scope of neuro-degenerative, auto-immune and inflammatory diseases, to finally adress ageing process in a preventive setting.




Neuro-Degeneration, Why we will make the difference